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Major Milestones in vaccine   development and licensing in IndiaMajor milestones in          vaccine development in India










 Efficacy trials onEfficacy trials on  First plagueFirst plague  First vaccine researchFirst vaccine research  Pasteur Ins tute of India.  DPT, DT and TT  Drug and Cosme cs
 vaccine discovered
 cholera vaccine conducted
 ins tute established at Kasauli,
 cholera vaccine conducted  vaccine discovered  institute established at Kasauli,  Coonoor, manufactured neural  Vaccine became available  Act enacted
 in Agra. India  by Dr. Ha ine  Himachal Pradesh   ssue an -rabies vaccine  in the country
 by Dr. Haffine
 in Agra. India
 Himachal Pradesh
 1904/
 1893  1897  1904/    1907                                 1920-                                1940
 1897
 1893
 1905
 1905                                                      1939













               Founding of Serum
 Freeze dried BCG
 Indigenous OPV
 UIP stated with six
 AEFI surveillance system
 BCG vaccine laboratory  Liquid BCG vaccine  Live attenvated freeze  Freeze dried BCG  Ins tute of India, Pune  Live attenvated freeze  Liquid BCG vaccine  BCG vaccine laboratory
 antigens (BCG, OPV, DT &
 established and initial
 vaccine and OPV
 Trivalent (sabin)
 set up in Guard;  became available in India  dried smallpox vaccine  vaccine and OPV  dried smallpox vaccine  became available in India  set up in Guindy;
 developed & produced
 guidelines were released
 became available.
 Measles in 1985)
 near Madras (Chennai)  as part of mass campaigns  became available  became available.  became available  as part of mass campaign  near Madras (Chennai)
 1985/               1966                                                      1951                            1948
 1967
 1948 1988  1951 1984  1965 1970  1967            1965






 Indian Vaccine CompanyIndian Vaccine Company
 Limited (IVCOL) and Bharat
 Limited (IVCOL) and Bharat  First ever recombinant  A fully-liquid                                 Development of
 Immunologicals and Biologicals  DNA hepa  s B   First vero cell culture   wP_based   Launch of H1N1 vaccine,   Meningococcal
 Immunologicals and Biologicals
 Rabies vaccine launched
 Limited (BIBCOL) were set up  First ever recombinant  Panacea Biotec  Two Indian Manufacturers   first indigenous vaccine   polysaccharide Vaccine
 Pentavalent
 Limited (BIBCOL) were set up
 vaccine
 by Human Biologicals
 Vaccine launched
 as public private joint   DNA hepatitis B vaccine  Pentavalent Vaccine launched by  developed influenza flu   against swine flu by   Group A & C (Bi Meningo)
 as public private joint
 developed in India
 A fully-liquid wP_based
 venture companies  developed in India by   Limited (HBL)  by Panacea Biotec  vaccine (Hib PRO, Hib)  Cadila Healthcare  by Bio-Med
 venture companies
 1989  1997 1997  2000  2005  2005  2007                   2010                                          2011
 1989







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